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iloperidone increases levels of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. Iloperidone is actually a time-dependent CYP3A inhibitor and may lead to greater plasma levels of drugs predominantly eradicated by CYP3A4.fedratinib will boost the level or result of diazepam by influencing hepatic enzyme CYP2C19 m